Week 16 NFL Predictions: Bills vs. Bears Odds, Start Time, Pick, Line, Spread, and How to Watch and Live Stream

Written by Robert Dexter December 25, 2022

Week 16 NFL Matchup: Buffalo Bills Quarterback Josh Allen Goes Head-to-Head with Chicago Bears Quarterback Justin Fields

Reported, Cold Weather Expected to Affect Running Quarterbacks in Week 16 Matchup Between Bears and Bills

The game will  Take Place at 1 p.m. ET at Soldier Field, Buffalo is Favored by Eight Points According to Caesars Sportsbook Odds

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Get Expert NFL Picks for Week 16 Bills vs. Bears Game from SportsLine's Advanced Computer Model

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Who will win the Bills vs. Bears game?